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Ever get a case of the blues? St. John's Wort may be just the thing. St. John's Wort has been traditionally used to battle minor depression. But it does not work for all depression, especially where there is an underlying problem. St. John's Wort may help for an occasional pick me up if you are suffering from mild depression, but if the depression is moderate, chronic, or severe, seek the advice of a professional. This plant cannot cure all of your problems.